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Description
The module will teach students about key aspects of biotechnology as it relates to the development of medicines for human use. Coverage will include a survey of the medical uses of vaccines, proteins and peptides. Students will learn about recombinant technology, protein purification, characterisation and formulation. A key focus of the module will be to ensure students understand the different classes of proteins (e.g. blood factors, antibodies, peptides) that are used clinically. Discussion will also cover regulatory issues, including biosimilars. Future perspective will be provided by covering companion diagnostics and principles of cell based therapies.
List of lectures:
- Introduction to pharmaceutical biotechnology
- Clinical use/classification and intro to protein therapeutics
- Introduction to monoclonal antibodies (PK properties/functions)
- Vaccines
- Monoclonal antibodies to treat cancer
- Protein purification-characterisation: overview
- Antibody-based medicines to treat inflammation
- Protein formulation/freeze drying
- Therapeutic proteins and peptides; need for half-life extension
- Protein purification/characterisation-2: concentration / determination
- Protein purification/characterisation-3: SDS PAGE/blotting
- Blood and anemia (EPO)
- Protein purification/characterisation-4: separation by charge, size, affinity, hydrophobicity
- Coagulation factors and clot busters (thrombolytic)-which are enzymes
- Protein purification/characterisation-5: Determination of aggregation and immunogenicity
- CAR-T cell therapy
- Protein purification/characterization-6: Determination of protein activity/potency and -7: protein fingerprinting
- Insulin, GLP1 agonists (Exenatide once weekly) and other clinically used peptides; formulation to extend duration of action
- Formulations for parenteral and听intravitreal injection听and other novel delivery methods
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Module deliveries for 2024/25 academic year
Last updated
This module description was last updated on 8th April 2024.
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