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This module aims to provide an overview of the principles of fermentation technology and fermenter operation and a framework for the quantitative evaluation of fermentation process productivity and yield. In addition, this module focuses on the engineering characterisation of fermentation processes (from a mixing, power input and oxygen transfer perspective) and on the use of miniaturised and high throughput fermentation technologies to enable rapid fermentation process development and scale-up. The underlying principles of fermentation, bioreactor characterisation and scaling are introduced through a series of lectures, which are supported by quantitative, problem-based case studies and the use of fermentation simulation software.

Upon completion of the course, a student should be able to:

• Gain in-depth knowledge required to select different expression systems and to formulate suitable growth media
• Specify fermenter operating conditions under different scenarios
• Quantify and evaluate fermentation process performance
• Clearly distinguish different bioreactor systems and their applications and appreciate the latest technology developments (perfusion modes, single-use reactors, etc)
• Gain in-depth knowledge required to design a fermenter in terms of mixing, power input and oxygen capabilities
• Understand how the engineering environment affects microbial growth kinetics
• Perform design calculations with regards to scale-up and scale-down of a fermentation process
• Appreciate how miniature and high throughput fermentation technologies can be used for the rapid acquisition of design data